Background:

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,Transcriptional repressor of genes that require a bHLH protein for their transcription.,Contains 1 basic helix-loop-helix (bHLH) domain.,Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.,

Classification:

Primary antibody

Alternative names:

Transcription factor HES-2 ;Class B basic helix-loop-helix protein 40;bHLHb40;Hairy and enhancer of split 2

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 40-120

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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