Background:

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

Classification:

Primary antibody

Alternative names:

Eukaryotic translation initiation factor 2-alpha kinase 4; EIF2AK4; GCN2; KIAA1338; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GCN2 around the phosphorylation site of Thr899. AA range:865-914

Concentration:

1 mg/ml

Molecular weight:

186838

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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