Background:

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.

Classification:

Primary antibody

Alternative names:

Docking protein 2; DOK2; Docking protein 2; Downstream of tyrosine kinase 2; p56;dok-2

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phospho-peptide around the phosphorylation site of human Dok-2 (phospho Tyr345)

Concentration:

1 mg/ml

Molecular weight:

45379

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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