Background:

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Classification:

Primary antibody

Alternative names:

Crk-like protein; CRKL; Crk-like protein

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CrkL around the phosphorylation site of Tyr207. AA range:173-222

Concentration:

1 mg/ml

Molecular weight:

33777

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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