Background:

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Classification:

Primary antibody

Alternative names:

Bmi-1; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Recombinant Protein derived from human Bmi-1

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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