Background:

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Beta-secretase 2 ;EC 3.4.23.45;Aspartic-like protease 56 kDa;Aspartyl protease 1;ASP1;Asp 1;Beta-site amyloid precursor protein cleaving enzyme 2;Beta-site APP cleaving enzyme 2;Down reg

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 210-290

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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