Background:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins| composed of a ligand-binding extracellular domain with cysteine-rich region| a transmembrane domain| and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding| resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular

Classification:

Primary antibody

Alternative names:

Activin receptor type-1 ;EC 2.7.11.30;Activin receptor type I;ACTR-I;Activin receptor-like kinase 2;ALK-2;Serine/threonine-protein kinase receptor R1;SKR1;TGF-B superfamily receptor type

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from part region of human protein

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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