Background:

Actins are highly conserved proteins that are involved in various types of cell motility| and maintenance of the cytoskeleton. In vertebrates| three main groups of actin isoforms| alpha| beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton| and as mediators of internal cell motility. Actin| gamma 1| encoded by this gene| is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26| a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Actin; cytoplasmic 2 ;Gamma-actin [Cleaved into: Actin; cytoplasmic 2; N-terminally processed]

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from part region of human protein

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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