Background:

Acetylation of lysine| like phosphorylation of serine| threonine or tyrosine| is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A| H2B| H3| and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones| transcription factors| and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity| cell growth| differentiation| and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism| longevity| actin polymerization| and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases| and HDACs have become promising targets for anti-cancer drugs currently in development.

Classification:

Primary antibody

Alternative names:

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized acetyl-peptide derived from human acetylation Lys proteins.

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

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