Background:

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus| and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions| and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues| indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon| suggesting a function of this protein in downregulating interferon responses| independent of its isopeptidase activity towards ISG15.

Classification:

Primary antibody

Alternative names:

UBP18

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human UBP18

Concentration:

1 mg/ml

Molecular weight:

40920

Applications:

WB

Storage:

-20°C for 1 year

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