Background:

Troponin is a central regulatory protein of striated muscle contraction| and together with tropomyosin| is located on the actin filament. Troponin consists of 3 subunits: TnI| which is the inhibitor of actomyosin ATPase; TnT| which contains the binding site for tropomyosin; and TnC| the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI| thus allowing the interaction of actin with myosin| the hydrolysis of ATP| and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

Classification:

Primary antibody

Alternative names:

TNNC1

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human TNNC1

Concentration:

1 mg/ml

Molecular weight:

17710

Applications:

WB

Storage:

-20°C for 1 year

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