Background:

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways| mediating cellular proliferation| survival| and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues| thus may function in signaling pathways utilized broadly during fetal development| and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway| and knockout mice have been shown to develop spontaneous tumors| suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

TNK1 ;Tyr277 ; Non-receptor tyrosine-protein kinase TNK1; EC 2.7.10.2; CD38 negative kinase 1

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human TNK1 (Tyr277)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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