Background:

The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family| and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy| as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR)| which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

TCPR2

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human TCPR2

Concentration:

1 mg/ml

Molecular weight:

155210

Applications:

WB

Storage:

-20°C for 1 year

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