Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands| such as IL2| IL4| CSF1| and different growth hormones. It has been shown to be involved in diverse biological processes| such as TCR signaling| apoptosis| adult mammary gland development| and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Classification:

Primary antibody

Alternative names:

Stat5 ;Tyr694; Signal transducer and activator of transcription 5B

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human Stat5 (Tyr694)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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