Background:

The protein encoded by this gene is a subunit of a heterodimer that| along with SUPT16H| forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described| but its full-length nature is not known.

Classification:

Primary antibody

Alternative names:

SSRP1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human SSRP1

Concentration:

1 mg/ml

Molecular weight:

77990

Applications:

WB

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

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