Background:

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2)| is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to| but distinct from| the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia| SCA5| that is characterized by neurodegeneration| progressive locomotor incoordination| dysarthria| and uncoordinated eye movements.

Classification:

Primary antibody

Alternative names:

SPTN2

Species reactivity:

Human, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human SPTN2

Concentration:

1 mg/ml

Molecular weight:

262900

Applications:

WB

Storage:

-20°C for 1 year

More info:

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