Background:

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton| and functions in the determination of cell shape| arrangement of transmembrane proteins| and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin| which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders| including elliptocytosis type 2| pyropoikilocytosis| and spherocytic hemolytic anemia.

Classification:

Primary antibody

Alternative names:

SPTA1

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human SPTA1

Concentration:

1 mg/ml

Molecular weight:

266090

Applications:

WB

Storage:

-20°C for 1 year

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