Background:

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding| this complex translocates to the cytoplasm| where it interacts with TGF-beta receptor type-1 (TGFBR1)| leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

Smad7 ;Acetyl Lys70; Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human Smad7 (Acetyl Lys70)

Concentration:

1 mg/ml

Molecular weight:

46860

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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