Background:

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease| the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants| some encoding different isoforms and others that have not been fully characterized.

Classification:

Primary antibody

Alternative names:

SIAH1

Species reactivity:

Human, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human SIAH1

Concentration:

1 mg/ml

Molecular weight:

31020

Applications:

WB

Storage:

-20°C for 1 year

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