Background:

This gene encodes a protein that appears to be a component the radial spoke head| as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes| which are regularly spaced along cilia| sperm| and flagella axonemes| consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1| a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

RSH4A

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human RSH4A

Concentration:

1 mg/ml

Molecular weight:

78760

Applications:

WB

Storage:

-20°C for 1 year

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