Background:

This gene encodes a protein containing a C3HC4-type RING finger domain| which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain| which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease| a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases| where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2| and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

RN213

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human RN213

Concentration:

1 mg/ml

Molecular weight:

572770

Applications:

IHC-p, IF

Storage:

-20°C for 1 year

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