Background:

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus| although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing| including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present| thus coupling pre- and post-mRNA splicing events. Previously| it was thought that two genes encode this protein| RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene| which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome.

Classification:

Primary antibody

Alternative names:

RBM8A

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human RBM8A

Concentration:

1 mg/ml

Molecular weight:

19140

Applications:

WB

Storage:

-20°C for 1 year

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