Background:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family| also known as the T1B family| that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion| a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants

Classification:

Primary antibody

Alternative names:

PSB3

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human PSB3

Concentration:

1 mg/ml

Molecular weight:

22550

Applications:

WB

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

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