Background:

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes| complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7| beta-1 to -7| beta-1 to -7| and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307)| beta-2 (PSMB7; MIM 604030)| and beta-5 (PSMB5; MIM 600306). Three additional subunits| beta-1i (PSMB9; MIM 177045)| beta-2i (PSMB10; MIM 176847)| and beta-5i (PSMB8; MIM 177046)| are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11| or beta-5t| is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al.| 2007

Classification:

Primary antibody

Alternative names:

PSB11

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human PSB11

Concentration:

1 mg/ml

Molecular weight:

33000

Applications:

WB

Storage:

-20°C for 1 year

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