Background:

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage| the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly| seizures| and developmental delay.

Classification:

Primary antibody

Alternative names:

PNK1 ;Ser114/Thr118; Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphatase [Includes: Polynucleotide 3'-phosphatase; EC 3.1.3.32; 2';3'-polynucleotidase; Polynucleotide 5'-hydroxyl-kinase; EC 2.7.1.78;

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human PNK1 (Ser114 and Thr118)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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