Background:

This gene encodes a member of the phospholipase C family| which catalyze the hydrolysis of phosphatidylinositol 4|5-bisphosphate to generate the second messengers diacylglycerol and inositol 1|4|5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine| sphingosine| and several phospholipids.

Classification:

Primary antibody

Alternative names:

PLCD3

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human PLCD3

Concentration:

1 mg/ml

Molecular weight:

86790

Applications:

WB

Storage:

-20°C for 1 year

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