Background:

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice| expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Classification:

Primary antibody

Alternative names:

Pdcd-1; Programmed cell death protein 1; Protein PD-1; hPD-1; CD antigen CD279

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human Pdcd-1

Concentration:

1 mg/ml

Molecular weight:

31680

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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