Background:

This gene is a member of the protocadherin gamma gene cluster| one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization| suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes| subfamily B contains 7 genes and 2 pseudogenes| and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large| variable region exons are followed by a constant region| containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region| which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Classification:

Primary antibody

Alternative names:

PCDGD

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human PCDGD

Concentration:

1 mg/ml

Molecular weight:

101970

Applications:

WB

Storage:

-20°C for 1 year

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