Background:

This gene encodes a protein that is conserved across metazoans. In vertebrates| this gene is linked in a head-to-head arrangement with the adjacent parkin gene| which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones| including heat shock proteins 70 and 90| and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients| and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

PACRG

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human PACRG

Concentration:

1 mg/ml

Molecular weight:

32560

Applications:

WB

Storage:

-20°C for 1 year

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