Background:

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg| which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8| 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Classification:

Primary antibody

Alternative names:

NTAN1

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human NTAN1

Concentration:

1 mg/ml

Molecular weight:

34100

Applications:

WB

Storage:

-20°C for 1 year

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