Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates| thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel| ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Classification:

Primary antibody

Alternative names:

NEDD4L ;Ser342 ; E3 ubiquitin-protein ligase NEDD4-like; EC 6.3.2.-; NEDD4.2; Nedd4-2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human NEDD4L (Ser342)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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