Background:

alternative products:Additional isoforms seem to exist|Catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.|cofactor:Binds 1 zinc ion per subunit.|cofactor:Calcium.|disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Strongly inhibited by TIMP-2| TIMP-3 and TIMP-4| while TIMP-1 is less efficient.|Endopeptidase that degrades various components of the extracellular matrix| such as aggrecan and cartilage oligomeric matrix protein (comp)| during development| haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV| laminin| nidogen| nascin-C isoform| fibronectin| and type I gelatin.|PTM:Activated by autolytic cleavage after Lys-97.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|tissue specificity:Expressed in mammary gland| placenta| lung| pancreas| ovary| small intestine| spleen| thymus| prostate| testis colon| heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.|

Classification:

Primary antibody

Alternative names:

MMP19 ;Cleaved-Tyr98; Matrix metalloproteinase-19; MMP-19; EC 3.4.24.-; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)

Concentration:

1 mg/ml

Molecular weight:

55880

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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