Background:

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans| two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages| while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts| endothelial cells| epithelial cells| melanocytes| etc.). However| L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Classification:

Primary antibody

Alternative names:

LCP1 ;Tyr28; Plastin-2; L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human LCP1 (Tyr28)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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