Background:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling| both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores| PKC activation| MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1| GRB2| GRAP2| and other signaling molecules.|miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC| maybe by inducing the dephosphorylation of LAT.|PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.|PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation| or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.|subcellular location:Present in lipid rafts.|subunit:When phosphorylated| interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2| GRAP| GRAP2| PLCG1 and PLCG2. Interacts indirectly with CBL| SOS| VAV| and LCP2. Interacts with SHB| SKAP2 and CLNK (By similarity). Interacts with FCGR1A.|tissue specificity:Expressed in thymus| T-cells| NK cells| mast cells and| at lower levels| in spleen. Present in T-cells but not B-cells (at protein level).|

Classification:

Primary antibody

Alternative names:

LAT ;Phospho Tyr255; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human LAT (Phospho Tyr255)

Concentration:

1 mg/ml

Molecular weight:

28820

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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