Background:

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1| beta 3| beta 5| beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Classification:

Primary antibody

Alternative names:

ITGAV ;light chain; Cleaved-Asp891; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51; Integrin alpha-V heavy chain; Integrin alpha-V light chain;

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human ITGAV (light chain| Cleaved-Asp891)

Concentration:

1 mg/ml

Molecular weight:

115280

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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