Background:

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain| yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin| this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL)| and in addition to a role in adhesion| it may serve as an accessory molecule for IEL activation.

Classification:

Primary antibody

Alternative names:

ITGAE ;light chain; Cleaved-Arg177; Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103; Integrin alpha-E light chain; Integrin alpha-E heavy chain;

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human ITGAE (light chain| Cleaved-Arg177)

Concentration:

1 mg/ml

Molecular weight:

129690

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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