Background:

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway| which regulates glucose uptake and release| as well as the synthesis and storage of carbohydrates| lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome| Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Insulin Receptor β ;Tyr1345 ; Insulin receptor; IR; EC 2.7.10.1; CD antigen CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta;

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human Insulin Receptor β (Tyr1345)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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