Background:

disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.|Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.|pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32| Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival| transformation and tumorigenicity.|PTM:Acetylation by CBP| which is induced by peroxidase stress| inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.|PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.|Contains 1 fork-head DNA-binding domain.|subcellular location:When phosphorylated| translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.|subunit:Interacts with CBP| MYOCD| SIRT1| SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.|tissue specificity:Heart| brain| placenta| lung| liver| skeletal muscle| kidney and pancreas. Isoform zeta is most abundant in the liver| kidney| and pancreas.|

Classification:

Primary antibody

Alternative names:

FoxO4 ;Acetyl Lys407; Forkhead box protein O4; Fork head domain transcription factor AFX1

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human FoxO4 (Acetyl Lys407)

Concentration:

1 mg/ml

Molecular weight:

55550

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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