Background:

The filaggrin-like protein encoded by this gene is upregulated by calcium| proteolyzed by calpain 1| and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin| with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact| in addition to providing a physical barrier| C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.

Classification:

Primary antibody

Alternative names:

FILA2

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human FILA2

Concentration:

1 mg/ml

Molecular weight:

263010

Applications:

WB

Storage:

-20°C for 1 year

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