Background:

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa| which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions| membrane phospholipids| and factor VIII. Alterations of this gene| including point mutations| insertions and deletions| cause factor IX deficiency| which is a recessive X-linked disorder| also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Classification:

Primary antibody

Alternative names:

FA9 ;heavy chain; Cleaved-Val227; Coagulation factor IX; EC 3.4.21.22; Christmas factor; Plasma thromboplastin component; PTC; Coagulation factor IXa light chain; Coagulation factor IXa heavy chain;

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human FA9 (heavy chain| Cleaved-Val227)

Concentration:

1 mg/ml

Molecular weight:

50710

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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