Background:

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter| thyroperoxidase| and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase| lactoperoxidase| and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Classification:

Primary antibody

Alternative names:

DUOX1

Species reactivity:

Human, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human DUOX1

Concentration:

1 mg/ml

Molecular weight:

170610

Applications:

WB

Storage:

-20°C for 1 year

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