Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily| and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L)| and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD| a death domain containing adaptor protein| is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Classification:

Primary antibody

Alternative names:

DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD antigen CD262

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human DR5

Concentration:

1 mg/ml

Molecular weight:

48400

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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