Background:

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes| two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants| each of which encodes a different isoform| have been identified.

Classification:

Primary antibody

Alternative names:

Transcriptional repressor NF-X1 ;EC 6.3.2.-;Nuclear transcription factor; X box-binding protein 1

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 80-160

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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