Background:

This gene encodes a member of the PSCD family of proteins| which have an N-terminal coiled-coil motif| a central Sec7 domain| and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization| the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity| and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs)| which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5| but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene.

Classification:

Primary antibody

Alternative names:

CYH4

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human CYH4

Concentration:

1 mg/ml

Molecular weight:

43340

Applications:

WB

Storage:

-20°C for 1 year

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