Background:

This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled| a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition| the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides| localize to promoters and CpG islands| and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2| an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans| a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

CXXC4

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human CXXC4

Concentration:

1 mg/ml

Molecular weight:

21780

Applications:

WB

Storage:

-20°C for 1 year

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