Background:

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates| such as 8-oxo-dGTP| 8-oxo-dATP| 2-hydroxy-dATP| and 2-hydroxy rATP| to monophosphates| thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm| with some in the mitochondria| suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants| some of which encode distinct isoforms| have been identified. Additional variants have been observed| but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional| longer is

Classification:

Primary antibody

Alternative names:

7; 8-dihydro-8-oxoguanine triphosphatase ;EC 3.6.1.55;2-hydroxy-dATP diphosphatase;EC 3.6.1.56;8-oxo-dGTPase;Nucleoside diphosphate-linked moiety X motif 1;Nudix motif 1

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human protein . at AA range: 1-80

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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