Background:

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone| cornea| dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV| Ehlers-Danlos syndrome type VIIA| Ehlers-Danlos syndrome Classical type| Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor. Two transcripts| resulting from the use of alternate polyadenylation signals| have been identified for this gene.

Classification:

Primary antibody

Alternative names:

Collagen I α1 ;Cleaved-Ala1218; Collagen alpha-1;I chain; Alpha-1 type I collagen

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human Collagen I α1 (Cleaved-Ala1218)

Concentration:

1 mg/ml

Molecular weight:

161040

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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