Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L)| which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells| expression of cell surface markers| and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Signal transducer and activator of transcription 6; STAT6; Signal transducer and activator of transcription 6; IL-4 Stat

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Tyr641. AA range:608-657

Concentration:

1 mg/ml

Molecular weight:

94135

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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