Background:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha| interferon-gamma| EGF| PDGF and IL6. This protein mediates the expression of a variety of genes| which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Classification:

Primary antibody

Alternative names:

Signal transducer and activator of transcription 1-alpha/beta; STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human STAT1 around the phosphorylation site of Tyr701. AA range:668-717

Concentration:

1 mg/ml

Molecular weight:

87335

Applications:

IF, ICC, WB, IHC-p, IP, ELISA

Storage:

-20°C for 1 year

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