Background:

This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site| together with the large subunit of U2 auxiliary factor (U2AF)| and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif| a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence| a zinc knuckles domain| and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Splicing factor 1; SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162

Species reactivity:

Human, Mouse, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SF1 around the phosphorylation site of Ser82. AA range:48-97

Concentration:

1 mg/ml

Molecular weight:

68330

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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